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pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can decrease panobinostat stages by ~70% and cause treatment method failure.pentobarbital will reduce the extent or outcome of alosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insigni